First, "if one of the many many many different solutions aren't adequate for some reason" was there for a reason.

Second, no, it isn't. Pypy is really fast compared to Python. "Compared to Python" is just about the lowest bar there is, though. In absolute terms it is still only a medium-fast language runtime, and it comes with a lot of costs and tradeoffs.

That's the problem with Python. Lots of ways to take a very slow language and make it a medium-fast language with substantial tradeoffs, or make it a fast language with enormous tradeoffs. If you can handle the tradeoffs, fine. But if you can't you just need to switch to a language that is fast without anywhere near as many tradeoffs.