TailScale uses WireGuard. Essentially an easy-to-use wrapper with some nice mesh networking capabilities. Quick to spin up. Easy to use.

If you've already installed WG, ZT, and OpenVPN you should know all this, I think.

I've always uses OpenVPN for both business (their Access Server product) and for my own homelab (CloudConnexa). Maybe I'm biased. Been using OpenVPN in one way for over 10 years.