Best of luck to Craig. If you don't know who he is, he's the reason we call(ed) Twitter posts 'tweets' [1] and also wrote perhaps the first pre-SDK iPhone app from the outside [2].

[1] https://furbo.org/2013/06/28/the-origin-of-tweet/

[2] https://furbo.org/2007/08/19/mobiletwitterrific/

When my wife was diagnosed with stage 3 bowel cancer earlier this year, she was essentially prepared to die. She didn't even cry once. Her father had died from the same cancer at around the same age as her (early 40s), in the most horrific way imaginable. Her father used to work for the Soviet military in charge of a team of people who worked on propaganda so he was a strong believer in communism and he was devastated by the collapse of the USSR; his entire world had fallen apart. But then bowel cancer finished him off. My wife was in her teens at the time and she said he was extremely angry and not himself for years until he died. The chemo made him extremely sick, destroyed his body, and he had to have a colostomy bag. Years later, after my wife met me, we experienced a lot of hardship together; just one episode of bad luck after another... Like, almost every aspect of our lives which we didn't control. So by the time she got her cancer diagnosis, it's as though she was expecting it.

It turns out that she has a relatively rare genetic condition which increases the probability of bowel cancer by about 10x... These cancers are known to respond very poorly to standard chemo (and likely explains her father's horrible death decades earlier). This is where our luck finally turned though. We got lucky, possibly for the first time since we've been together. Her cancer turned out to be a kind which is highly responsive to immunotherapy. The most recent trial for the relevant class of drugs showed an unprecedented 100% complete response in about 40 patients (Dostarlimab). Moreover, that same class of (very expensive) drugs became available for her exact case, on the subsidized public list in my country, just one month prior to her diagnosis. After her first month of treatment, the tumor had shrunk by like 50% in diameter. Now, 5 months later, there is no evidence of cancer on the MRI.

I feel like the experience has completely changed my wife's perspective of life in a fundamental way. Before this, she lived her entire life expecting that things never get better and all news is bad news. Systems decay, collapse and people die.

These days I often think about the ancient Chinese tale "The old man lost his horse." It's insane how little control we actually have over the most important aspects of our lives and how something terrible (like a tumor which doesn't respond to chemo) can become a positive (but responds extremely well to immunotherapy). Also, it's quite inspiring to think about how people identified this horrible class of the most untreatable cancers in existence and decided to do something about it, and now it seems like they've become the most treatable of all cancers, with the fewest side effects too. It's a testament to the good things innovation can create when people focus on the worst problems, the worst injustices of human existence.

I lost my mum nearly 4 weeks ago to cancer.

This was the third time, and the second metastasis. This time round, the spread was very advanced and encompassed her internal organs, even surrounding the port catheter.

She knew this time would be her last, so she tried to help us prepare. But it wasn’t enough. It’s never enough. I guess my emotions are still raw that I’m struggling to work and keep to life’s commitments but I try. My mother’s resilience is embodied in what she taught me as a young child through to adulthood.

This time, only a month and a week ago, she had lost too much weight for another round of chemo. The medical intervention was purely palliative: CSCI and fluids.

She passed away at 0929, not long after my father arrived after I had spent the night in hospital with her. The last thing she asked me for that morning was a sip of tea.

> Anyone who exercises regularly knows that there are always plenty of reasons to avoid it: you didn’t sleep well, you have an important project to finish, or you’re sore from a previous workout.

Ahnold Schwarzenegger remarked that the improvements come when your really don't want to exercise, but do it anyway.

I’m not sure there’s anything that evokes a more discordant set of emotions in me than an optimistic cancer fighter. I feel fear, frustration, hope, joy, confusion, anger…

When I was a teen I watched my mom battle cancer to a draw. Only in my late 30s did the repressed memories start returning. I got to remember her voice again, but I also got to remember the rest. And now my only plan is to just not get cancer, because it’s all far too much to even think about.

I don’t pity Craig, I envy him. I’m jealous, even. Because he’s discovered or was always imbued with the power to fight an unfair battle on his terms. If it’s ever my turn I hope I can be like him.

The mundanity of the last paragraph made me smile. That desire to just go back to normal -walking, debugging, comfort- after moments like that is incredibly under-rated.

In case the author of the post reads these comments… Thank you very much for sharing this with us. My daughter had leukemia (ALL) at a young age - your post gives me a glimpse into how she might have experienced the treatment. She was too young at the time to be able to describe her how it felt.

Thank you for the authentic process and experience documentation. I enjoy the incorporation of these memories into my own self-world. Very valuable.

For context: https://furbo.org/2026/01/01/the-year-that-kicked-my-ass/

I don't know who you are but I wish you the best of luck. Keep your spirit up. I'm glad that medicine is slowly making progress in cancer therapies and I sincerely hope that we can completely beat it in the not so far future.

Methotrexate is such a gnarly drug, my partner was on it for rheumatoid arthritis for a little bit, but the side effects were too awful for her to continue it. Luckily there was alternatives. Didn't know it was used in chemo!

Sending well wishes. Enjoy the future swims.

Really hoping AI can accelerate more palatable cancer treatments. Wishing this guy a complete recovery.

Best of luck, hero. Reading the linked post in the beginning made me burst into tears. It's not fair to get all this shit coming your way in a lifetime, let alone one year. I hope you get only the best years from now on <3

> Everyone experiences chemotherapy differently. Just as every body is different, so is the reaction to the chemicals that are killing the cancer.

Well, this is true, but generic chemotherapeutics target pretty much all cells. That's why there are so many side effects.

There are some partial work arounds, e. g. targeting some specific cells via monoclonal antibodies, but even these have side effects. I understand the rationale of stopping uncontrolled cell growth, but chemotherapeutics are hugely damaging to all cells, not just cancer cells. And it is often unclear whether these have a really profound positive impact. For instance, if you kill 80% of the cancer cells but the cost is that the other cells are significantly weakened, leading to a death due to that, then you have a trade-off that isn't so great.

Godspeed, sir.

Get well soon